Effects of obstacles on inertial focusing and separation in sinusoidal channels: An experimental and numerical study
نویسندگان
چکیده
Inertial microfluidics manipulates and separates microparticles based on the finite inertia of fluid at high flow speed. In inertial microfluidics, modifying geometry by embedding periodic micro-obstacles into curvilinear channels is emerging as a promising strategy to improve focusing separation. This work systematically investigated influence developed high-resolution microfluidic device for particle cell First, we numerical modelling simulate migration trajectories particles. Then, studied effects various obstacles in sinusoidal channels. The concave were more effective tuning separation than convex obstacles. Furthermore, square obstacle channel could offer highest resolution. Finally, channel, applied it high-efficiency polystyrene beads U87MG cancer cells from blood.
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ژورنال
عنوان ژورنال: Chemical Engineering Science
سال: 2023
ISSN: ['1873-4405', '0009-2509']
DOI: https://doi.org/10.1016/j.ces.2023.118826